Cancer therapy: Tumours switch to resist

Nature. 2012 Oct 18;490(7420):347-8. doi: 10.1038/nature11489. Epub 2012 Oct 10.

Abstract

Tumour cells can respond to targeted immune-cell therapies by losing proteins that mark them as being cancerous. Subverting this resistance mechanism may lead to more durable cancer-treatment strategies.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Cell Dedifferentiation*
  • Humans
  • Immunotherapy*
  • Inflammation / pathology*
  • Melanoma / pathology*
  • Melanoma / therapy*
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / transplantation*