Since its discovery more than a decade ago, H3K4 methylation has become synonymous with transcription. We only now have begun to realize that the distinct states of H3K4 methylation have unique distributions and specialized roles in other chromatin-related processes. Here, I discuss recent findings addressing their regulation and functions.
Keywords: H3K4 methylation; KMT2; MLL; Set1; Trr; Trx; chromatin; transcription.