Abstract
Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.
Keywords:
BRCA1; breast cancer; epigenetic regulation; miR-155; micro RNA; transcription.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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BRCA1 Protein / chemistry
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BRCA1 Protein / genetics*
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BRCA1 Protein / metabolism*
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Breast Neoplasms / genetics*
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Breast Neoplasms / metabolism*
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Carrier Proteins / metabolism
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Epigenesis, Genetic*
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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MicroRNAs / genetics
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MicroRNAs / metabolism
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Protein Binding
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Protein Interaction Domains and Motifs
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Transcription, Genetic*
Substances
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BRCA1 Protein
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Carrier Proteins
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MicroRNAs