The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression

Transcription. 2013 Jan-Feb;4(1):24-8. doi: 10.4161/trns.22600. Epub 2012 Nov 6.

Abstract

Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.

Keywords: BRCA1; breast cancer; epigenetic regulation; miR-155; micro RNA; transcription.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • BRCA1 Protein / chemistry
  • BRCA1 Protein / genetics*
  • BRCA1 Protein / metabolism*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism*
  • Carrier Proteins / metabolism
  • Epigenesis, Genetic*
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Transcription, Genetic*

Substances

  • BRCA1 Protein
  • Carrier Proteins
  • MicroRNAs