Roles of peptidoglycan recognition protein (PGRP) in immunity and implications for novel anti-infective measures

Crit Rev Eukaryot Gene Expr. 2012;22(3):259-68. doi: 10.1615/critreveukargeneexpr.v22.i3.90.

Abstract

Peptidoglycan recognition protein (PGRP) is an important host innate immunity arm capable of peptidoglycan and allied bacteria recognition. PGRP belongs to host pattern recognition receptors (PRRs) responsible for pathogen associated molecular patterns recognition, such as lipopolysaccharide, lipoteichoic acid, PGN, and mannose. As an essential host PRR, PGRP is well conserved from insects to mammals. The distribution, structure, function, regulation of gene expression, and evolution of PGRP from insects and mammals were summarized to furnish insights into this important molecule family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amidohydrolases / metabolism
  • Animals
  • Bacteria / immunology
  • Carrier Proteins / genetics
  • Carrier Proteins / immunology*
  • Carrier Proteins / metabolism*
  • Catechol Oxidase / metabolism
  • Enzyme Precursors / metabolism
  • Gene Expression Regulation
  • Humans
  • Immunity, Innate*
  • Insecta / immunology
  • Lipopolysaccharides / metabolism
  • Mannose / metabolism
  • Peptidoglycan / metabolism
  • Receptors, Pattern Recognition / genetics
  • Receptors, Pattern Recognition / immunology*
  • Receptors, Pattern Recognition / metabolism
  • Signal Transduction
  • Teichoic Acids / metabolism

Substances

  • Carrier Proteins
  • Enzyme Precursors
  • Lipopolysaccharides
  • Peptidoglycan
  • Receptors, Pattern Recognition
  • Teichoic Acids
  • peptidoglycan recognition protein
  • lipoteichoic acid
  • pro-phenoloxidase
  • Catechol Oxidase
  • Amidohydrolases
  • amidase
  • Mannose