Correlation between resistance to pyrazinamide and resistance to other antituberculosis drugs in Mycobacterium tuberculosis strains isolated at a referral hospital
J Bras Pneumol. 2012 Sep-Oct;38(5):630-3.
doi: 10.1590/s1806-37132012000500013.
[Article in
English,
Portuguese]
Affiliation
- 1 Professor Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. lsfonseca@micro.ufrj.br
Abstract
The correlation between resistance to pyrazinamide (PZA) and resistance to other first-line antituberculosis drugs was investigated in 395 Mycobacterium tuberculosis strains isolated from clinical specimens, representing 14% of the overall number of M. tuberculosis isolates obtained between 2003 and 2008 at the laboratory of a referral university hospital for tuberculosis. A high correlation was found between resistance to PZA and multidrug resistance, as well as between PZA resistance and resistance to rifampin, isoniazid, and ethambutol (p < 0.01 for all). These results highlight the importance of performing PZA susceptibility testing prior to the prescription of this drug in order to treat drug-resistant and multidrug-resistant tuberculosis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antitubercular Agents / pharmacology*
-
Drug Resistance, Multiple, Bacterial / drug effects*
-
Humans
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / isolation & purification
-
Pyrazinamide / pharmacology*
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Tuberculosis, Pulmonary / microbiology
Substances
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Antitubercular Agents
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Pyrazinamide