Bronchodilatory and cardiovascular effects of an ethanol extract of Bacopa monniera in anaesthetized rats

A Dar; S Channa

doi:10.1016/S0944-7113(97)80040-2

Bronchodilatory and cardiovascular effects of an ethanol extract of Bacopa monniera in anaesthetized rats

Phytomedicine. 1997 Dec;4(4):319-23. doi: 10.1016/S0944-7113(97)80040-2.

Authors

A Dar¹, S Channa

Affiliation

¹ Pharmacology Section H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.

PMID: 23195581
DOI: 10.1016/S0944-7113(97)80040-2

Abstract

The bronchodilatory effect of the ethanol extract of Bacopa monniera on anaesthetized rats was studied. The extract antagonized the bronchoconstrictor action of carbachol. The bronchodilatory property shown by the plant extract (50 mg/kg) is reflected by a reduction in expiratory pressure which resembled more a salbutamol induced effect as compared with isoprenaline. The bronchodilatory action of the plant extract is probably mediated jointly by β-adrenoceptor dependent and independent mechanisms. Thus providing a rationale for its traditional use in the treatment of asthma.