Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression

Abstract

Experimental autoimmune uveoretinitis (EAU), a mostly T-cell dependent disease, was induced in laboratory animals by a single immunization with retinal extract or purified S-antigen in complete Freund's adjuvant. It can be prevented or suppressed by injections of either the autoantigen or monoclonal antibodies against the autoantigen. The suppression of EAU by these antibodies was associated with an anti-idiotypic antibody response. The inhibition of the pathogenic immune response by the antigen or the antibodies could be explained, according to Jerne's hypothesis of immunoregulation, by a disturbance of the network of idiotype and anti-idiotype interactions.