Orthogonal synthesis of a heterodimeric ligand for the development of the Gd(III)-Ga(III) ditopic complex as a potential pH-sensitive MRI/PET probe

Org Biomol Chem. 2013 Feb 13;11(10):1683-90. doi: 10.1039/c2ob27200h.

Abstract

A heterodimeric polyaminocarboxylate ligand based on a DO3A-sulfonamide linked to AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetracarboxylic acid) was synthesised via an orthogonal pathway in order to differentiate the two chelating cages and allow the formation of a Gd(III)-Ga(III) heteroditopic complex. The goal is to create a smart MRI/PET probe with pH dependent relaxivity and with the bimodal imaging approach that enables direct quantification of the stimulus, in this case pH. A (1)H NMR relaxometric study of the Gd-Ga heteroditopic complex addressed the pH modulation of the relaxivity and thus its possible use as an MRI pH sensitive probe.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media* / chemical synthesis
  • Contrast Media* / chemistry
  • Dimerization
  • Gadolinium / chemistry
  • Gallium / chemistry
  • Hydrogen-Ion Concentration
  • Ligands
  • Magnetic Resonance Imaging*
  • Molecular Probes* / chemical synthesis
  • Molecular Probes* / chemistry
  • Molecular Structure
  • Organometallic Compounds* / chemical synthesis
  • Organometallic Compounds* / chemistry
  • Positron-Emission Tomography*

Substances

  • Contrast Media
  • Ligands
  • Molecular Probes
  • Organometallic Compounds
  • Gadolinium
  • Gallium