Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars

Adv Mater. 2013 Jun 11;25(22):3055-61. doi: 10.1002/adma.201204623. Epub 2013 Feb 13.

Abstract

Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic
  • Gold / chemistry*
  • Humans
  • Lasers*
  • Metal Nanoparticles / chemistry*
  • Mice
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / therapeutic use

Substances

  • Photosensitizing Agents
  • Gold