Biosynthesis of drosopterins, the red eye pigments of Drosophila melanogaster

IUBMB Life. 2013 Apr;65(4):334-40. doi: 10.1002/iub.1145. Epub 2013 Feb 23.

Abstract

Drosophila melanogaster has red eyes. Scientists have been curious about the biosynthesis of the red eye pigments and have completed a number of investigations on these compounds. Scientific contributions made over the past 50 years have improved our understanding of the red eye pigments. Researchers have elucidated the chemical structures of some pigments and have successfully purified and identified the enzymes that participate in the biosynthesis of the red eye pigments. In this article, we will review the characteristics of the Drosophila red eye pigments and of the enzymes and genes involved in its biosynthetic pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila melanogaster / metabolism*
  • Eye / chemistry*
  • Eye / metabolism
  • GTP Cyclohydrolase / chemistry
  • GTP Cyclohydrolase / metabolism
  • Mutation
  • Pigments, Biological / biosynthesis*
  • Pteridines / chemistry
  • Pteridines / metabolism*

Substances

  • Pigments, Biological
  • Pteridines
  • drosopterin
  • GTP Cyclohydrolase