Genetic variation and biochemical properties of esterase-18 (ES-18) in the laboratory rat (Rattus norvegicus): a new locus of esterase cluster 2 in linkage group V

Biochem Genet. 1990 Feb;28(1-2):57-68. doi: 10.1007/BF00554821.

Abstract

A new liver-specific rat carboxylesterase isozyme (EC 3.1.1.1) designated esterase-18 (ES-18) is described. Genetic variation of ES-18 was examined in 93 inbred strains and substrains and a structural locus Es-18 was suggested, coding for either the presence (Es-18a) or the absence (Es-18b) of the isozyme. Linkage studies involving two backcross series revealed that Es-18 resides in cluster 2 of LGV. No recombination between Es-18 and other cluster 2 loci was found in 19 lines of two RI strain sets or in the backcross series.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carboxylesterase
  • Carboxylic Ester Hydrolases / genetics*
  • Crosses, Genetic
  • Genetic Linkage
  • Genetic Variation
  • Isoenzymes / genetics*
  • Liver / enzymology*
  • Multigene Family*
  • Phenotype
  • Rats / genetics*

Substances

  • Isoenzymes
  • Carboxylic Ester Hydrolases
  • Carboxylesterase