Congenital kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon successfully treated with low-dose radiation therapy

Pediatr Dermatol. 2014 Sep-Oct;31(5):595-8. doi: 10.1111/pde.12090. Epub 2013 Mar 5.

Abstract

Kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon is a life-threatening vasculopathy. The current mainstay treatment for KHEs is corticosteroids and chemotherapy, but these medications do not work for all patients and carry significant side effects. We report a neonate with a large congenital KHE who responded extremely well to low-dose radiation therapy.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Diagnostic Imaging
  • Hemangioendothelioma / congenital
  • Hemangioendothelioma / radiotherapy*
  • Humans
  • Infant, Newborn
  • Kasabach-Merritt Syndrome / congenital
  • Kasabach-Merritt Syndrome / radiotherapy*
  • Male
  • Prenatal Diagnosis
  • Radiotherapy Dosage
  • Sarcoma, Kaposi / congenital
  • Sarcoma, Kaposi / radiotherapy*

Supplementary concepts

  • Kaposiform Hemangioendothelioma