Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2061-4. doi: 10.1016/j.bmcl.2013.02.008. Epub 2013 Feb 13.

Abstract

A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Contrast Media* / administration & dosage
  • Contrast Media* / chemistry
  • Gastrointestinal Tract / metabolism*
  • Heterocyclic Compounds* / administration & dosage
  • Heterocyclic Compounds* / chemistry
  • Linear Models
  • Magnetic Resonance Imaging*
  • Mice
  • Mice, Inbred C3H
  • Molecular Structure
  • Organometallic Compounds* / administration & dosage
  • Organometallic Compounds* / chemistry
  • Sucrose* / administration & dosage
  • Sucrose* / chemistry

Substances

  • Contrast Media
  • Heterocyclic Compounds
  • Organometallic Compounds
  • Sucrose
  • gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate