Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma

J Clin Oncol. 2013 Jun 1;31(16):e254-8. doi: 10.1200/JCO.2012.46.4289. Epub 2013 Apr 22.
No abstract available

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology*
  • Biopsy
  • Carcinoma, Renal Cell / drug therapy*
  • Carcinoma, Renal Cell / genetics
  • Carcinoma, Renal Cell / metabolism
  • Carcinoma, Renal Cell / secondary
  • Disease Progression
  • Drug Resistance, Neoplasm*
  • Heterozygote
  • Humans
  • In Situ Hybridization, Fluorescence
  • Kidney Neoplasms / drug therapy*
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / metabolism
  • Kidney Neoplasms / pathology
  • Male
  • Methionine
  • Middle Aged
  • Point Mutation*
  • Proto-Oncogene Proteins c-met / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-met / genetics*
  • Pyrazines / administration & dosage
  • Pyrazines / pharmacology*
  • Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
  • Sequence Analysis, DNA
  • Threonine
  • Treatment Failure
  • Triazoles / administration & dosage
  • Triazoles / pharmacology*

Substances

  • 2-(4-(3-quinolin-6-ylmethyl-3H-(1,2,3)triazolo(4,5-b)pyrazin-5-yl)pyrazol-1-yl)ethanol
  • Antineoplastic Agents
  • Pyrazines
  • Triazoles
  • Threonine
  • Methionine
  • Proto-Oncogene Proteins c-met
  • RON protein
  • Receptor Protein-Tyrosine Kinases

Associated data

  • ClinicalTrials.gov/NCT00706355