The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast

Genetics. 2013 Jul;194(3):785-9. doi: 10.1534/genetics.113.150839. Epub 2013 May 1.

Abstract

The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.

Keywords: Dsn1; Ipl1/Aurora B protein kinase; chromosome segregation; kinetochore.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aurora Kinase B / genetics*
  • Aurora Kinase B / metabolism
  • Chromosomal Proteins, Non-Histone / genetics*
  • Chromosome Segregation*
  • Gene Expression Regulation, Fungal
  • Kinetochores / metabolism
  • Kinetochores / ultrastructure
  • Microtubules / metabolism
  • Microtubules / ultrastructure
  • Mitosis / genetics
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Phosphorylation
  • Protein Interaction Maps / genetics
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / genetics*

Substances

  • Chromosomal Proteins, Non-Histone
  • Dsn1 protein, S cerevisiae
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Aurora Kinase B