Abstract
The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.
Keywords:
Dsn1; Ipl1/Aurora B protein kinase; chromosome segregation; kinetochore.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aurora Kinase B / genetics*
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Aurora Kinase B / metabolism
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Chromosomal Proteins, Non-Histone / genetics*
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Chromosome Segregation*
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Gene Expression Regulation, Fungal
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Kinetochores / metabolism
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Kinetochores / ultrastructure
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Microtubules / metabolism
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Microtubules / ultrastructure
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Mitosis / genetics
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Phosphorylation
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Protein Interaction Maps / genetics
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae Proteins / genetics*
Substances
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Chromosomal Proteins, Non-Histone
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Dsn1 protein, S cerevisiae
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins
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Aurora Kinase B