Nanotechnology in diagnostics and therapeutics for gastrointestinal disorders

Dig Liver Dis. 2013 Dec;45(12):995-1002. doi: 10.1016/j.dld.2013.03.019. Epub 2013 May 7.

Abstract

This review describes the state of the art in nanoparticle and nanodevice applications for medical diagnosis and disease treatment. Nanodevices, such as cantilevers, have been integrated into high-sensitivity disease marker diagnostic detectors and devices, are stable over long periods of time, and display reliable performance properties. Nanotechnology strategies have been applied to therapeutic purposes as well. For example, nanoparticle-based delivery systems have been developed to protect drugs from degradation, thereby reducing the required dose and dose frequency, improving patient comfort and convenience during treatment, and reducing treatment expenses. The main objectives for integrating nanotechnologies into diagnostic and therapeutic applications in the context of intestinal diseases are reviewed.

Keywords: Diagnostics; Gastroenterology; Nanotechnology; Therapeutics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Colorectal Neoplasms / diagnosis
  • Dendrimers / therapeutic use
  • Gastrointestinal Diseases / diagnosis*
  • Gastrointestinal Diseases / therapy*
  • Humans
  • Inflammatory Bowel Diseases / drug therapy
  • Liposomes / therapeutic use
  • Nanomedicine*
  • Nanoshells / therapeutic use
  • Nanostructures / therapeutic use*
  • Nanowires
  • Quantum Dots

Substances

  • Dendrimers
  • Liposomes