Coniochaetones E-I, new 4H-chromen-4-one derivatives from the Cordyceps-colonizing fungus Fimetariella sp

Fitoterapia. 2013 Sep:89:8-14. doi: 10.1016/j.fitote.2013.04.011. Epub 2013 May 17.

Abstract

Five new 4H-chromen-4-one derivatives coniochaetones E-I (1-5), along with the known compounds coniochaetones B (6) and A (7) have been isolated from solid cultures of the Cordyceps-colonizing fungus Fimetariella sp. Their structures were elucidated primarily by NMR spectroscopy and the absolute configurations of compounds 1-3 were assigned using the modified Mosher's method. Compound 4 showed weak cytotoxic activity against HeLa cells with IC50 values of 72.8 μM. The co-isolated known compound 6 showed modest inhibitory effects against Aspergilus fumigates, Fusarium oxysporum and Fusarium nivale.

Keywords: Antifungal activity; Coniochaetone; Cordyceps-colonizing fungus; Cytotoxic activity; Structure elucidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Ascomycota / chemistry*
  • Aspergillus / drug effects
  • Biological Products / chemistry*
  • Biological Products / pharmacology
  • Biological Products / therapeutic use
  • Chromones / chemistry
  • Chromones / isolation & purification*
  • Chromones / pharmacology
  • Chromones / therapeutic use
  • Cordyceps*
  • Fusarium / drug effects
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Neoplasms / drug therapy

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Biological Products
  • Chromones
  • coniochaetone H
  • coniochaetone B