Abstract
A new C47 polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry
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Alkynes / pharmacology
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Animals
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Biological Factors / chemistry*
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Biological Factors / pharmacology*
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Cell Line, Tumor
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / pharmacology
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Humans
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K562 Cells
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Molecular Structure
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Polyynes / chemistry*
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Polyynes / pharmacology*
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Porifera / chemistry*
Substances
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Alkynes
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Biological Factors
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Fatty Acids, Unsaturated
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nepheliosyne A
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Polyynes