Abstract
We report a case of gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor (G-CSF). A 60- year-old man was admitted to our hospital complaining of upper abdominal pain. Endoscopic examination revealed a large type 5 advanced gastric cancer with bleeding from the low body of stomach to the antrum, accompanied with para-aortic and mesenteric lymph node metastasis. He had marked leukocytosis, and serum levels of G-CSF were elevated. Histological diagnosis of the biopsy specimen was adenosquamous carcinoma producing G-CSF. We attempted combination chemotherapy with docetaxel, cisplatin and S-1(DCS). After 1 course of treatment, the primary lesion was reduced in size. However, the size of the metastatic lymph node was larger. Chemotherapy was not effective enough, and the patient died 3 months after ending chemotherapy.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / biosynthesis
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Biomarkers, Tumor / blood*
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Biopsy
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Carcinoma, Adenosquamous / chemistry*
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Carcinoma, Adenosquamous / drug therapy
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Carcinoma, Adenosquamous / metabolism
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Carcinoma, Adenosquamous / pathology
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Cisplatin / therapeutic use
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Docetaxel
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Drug Combinations
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Fatal Outcome
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Granulocyte Colony-Stimulating Factor / blood*
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Granulocyte Colony-Stimulating Factor / chemistry
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Humans
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Male
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Oxonic Acid / therapeutic use
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Stomach Neoplasms / chemistry*
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Stomach Neoplasms / drug therapy
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Stomach Neoplasms / metabolism
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Stomach Neoplasms / pathology
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Taxoids / therapeutic use
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Tegafur / therapeutic use
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Tomography, X-Ray Computed
Substances
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Biomarkers, Tumor
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Drug Combinations
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Taxoids
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Granulocyte Colony-Stimulating Factor
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S 1 (combination)
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Tegafur
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Docetaxel
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Oxonic Acid
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Cisplatin