Candidate gene analysis: severe intraventricular hemorrhage in inborn preterm neonates

J Pediatr. 2013 Nov;163(5):1503-6.e1. doi: 10.1016/j.jpeds.2013.06.025. Epub 2013 Jul 26.

Abstract

Intraventricular hemorrhage (IVH) is a disorder of complex etiology. We analyzed genotypes for 7 genes from 224 inborn preterm neonates treated with antenatal steroids and grade 3-4 IVH and 389 matched controls. Only methylenetetrahydrofolate reductase was more prevalent in cases of IVH, emphasizing the need for more comprehensive genetic strategies.

Keywords: AGA; Appropriate for gestational age; BW; Birth weight; COL4A1; Collagen 4A1; Gr; Grade; IL; IVH; Interleukin; Intraventricular hemorrhage; MTHFR; Methylenetetrahydrofolate reductase; TNF; Tumor necrosis factor.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Birth Weight
  • Case-Control Studies
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Steroids / therapeutic use

Substances

  • Steroids
  • Methylenetetrahydrofolate Reductase (NADPH2)