Abstract
A vacuolar membrane protein, Vba2p of Schizosaccharomyces pombe, is involved in basic amino acid uptake by intact cells. Here we found evidence that Vba2p mediated ATP-dependent lysine uptake by vacuolar membrane vesicles of Saccharomyces cerevisiae. Vba2p was also responsible for quinidine sensitivity, and the addition of lysine improved cell growth on quinidine-containing media. These findings should be useful for further characterization of Vba2p.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / metabolism
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Amino Acid Transport Systems, Basic / genetics*
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Amino Acid Transport Systems, Basic / metabolism*
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Gene Expression
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Intracellular Membranes / metabolism*
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Lysine / metabolism
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Saccharomyces cerevisiae / cytology*
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Saccharomyces cerevisiae / genetics*
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Schizosaccharomyces / genetics*
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Schizosaccharomyces pombe Proteins / genetics*
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Schizosaccharomyces pombe Proteins / metabolism*
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Vacuoles / genetics*
Substances
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Amino Acid Transport Systems, Basic
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Schizosaccharomyces pombe Proteins
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Adenosine Triphosphate
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Lysine