Abstract
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
Keywords:
Hippo signaling; LATS1; LATS2; human cancer; protein kinase.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Animals, Genetically Modified
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Drosophila / genetics
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Drosophila / growth & development
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Female
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Genes, Tumor Suppressor*
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Humans
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Male
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Models, Genetic
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Mutation
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Neoplasms / genetics*
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Protein Serine-Threonine Kinases / genetics*
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RNA Interference
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Tumor Suppressor Proteins / genetics*
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Wings, Animal / growth & development
Substances
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Tumor Suppressor Proteins
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LATS1 protein, human
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LATS2 protein, human
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Protein Serine-Threonine Kinases