Abstract
We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthracenes
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Brain Neoplasms / drug therapy
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Brain Neoplasms / metabolism*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Humans
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Light
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Micelles
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Mitochondria / metabolism*
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Nanoparticles / administration & dosage
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Perylene / administration & dosage
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Perylene / analogs & derivatives*
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Phosphatidylethanolamines / chemistry
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Photochemotherapy*
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Photosensitizing Agents / administration & dosage*
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Polyethylene Glycols / chemistry
Substances
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Anthracenes
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Micelles
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Phosphatidylethanolamines
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Photosensitizing Agents
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1,2-distearoylphosphatidylethanolamine
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Polyethylene Glycols
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Perylene
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hypericin
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monomethoxypolyethylene glycol