Abstract
Molecular drug susceptibility testing was performed on 39 US patients with leprosy. Of these, 2 had dapsone-resistant Mycobacterium leprae and 1 of these patients also had rifampin-resistant M. leprae. Even though antileprosy drug resistance occurs in this leprosy population, resistance does not appear to be a major problem.
Keywords:
United States; drug resistance; leprosy.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Dapsone / pharmacology
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Drug Resistance, Bacterial*
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Genes, Bacterial
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Humans
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Leprosy / microbiology*
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Mycobacterium leprae / drug effects*
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Mycobacterium leprae / genetics
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Mycobacterium leprae / isolation & purification
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Polymerase Chain Reaction
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Rifampin / pharmacology
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Sequence Analysis, DNA
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United States
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Dapsone
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Rifampin