EGFR and EGFRvIII in glioblastoma: partners in crime

Gelareh Zadeh; Krishna P L Bhat; Kenneth Aldape

doi:10.1016/j.ccr.2013.09.017

EGFR and EGFRvIII in glioblastoma: partners in crime

Cancer Cell. 2013 Oct 14;24(4):403-4. doi: 10.1016/j.ccr.2013.09.017.

Authors

Gelareh Zadeh¹, Krishna P L Bhat, Kenneth Aldape

Affiliation

¹ Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5S 2J7, Canada.

PMID: 24135276
DOI: 10.1016/j.ccr.2013.09.017

Abstract

EGFRvIII, a mutated form of EGFR, plays a prominent role in tumorigenesis, but the underlying mechanisms have remained elusive. In this issue of Cancer Cell, Weiss and colleagues implicate phosphorylation of EGFRvIII by EGFR and the consequent phosphorylation of STAT3 as a signaling axis that drives transformation in glioblastoma.

Publication types

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MeSH terms

Brain Neoplasms / metabolism*
ErbB Receptors / metabolism*
Glioblastoma / metabolism*
Humans
STAT3 Transcription Factor / metabolism*
STAT5 Transcription Factor / metabolism*

Substances

STAT3 Transcription Factor
STAT3 protein, human
STAT5 Transcription Factor
epidermal growth factor receptor VIII
EGFR protein, human
ErbB Receptors