Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle

S Kealey; J Passchier; M Huiban

doi:10.1039/c3cc47203e

Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle

Chem Commun (Camb). 2013 Dec 14;49(96):11326-8. doi: 10.1039/c3cc47203e. Epub 2013 Oct 25.

Authors

S Kealey¹, J Passchier, M Huiban

Affiliation

¹ Institute of Psychiatry, King's College London, De Crespigny Road, Denmark Hill, London SE5 8AF, UK.

PMID: 24158034
DOI: 10.1039/c3cc47203e

Abstract

The Negishi coupling reaction between arylzinc halide reagents and (11)CH3I has been used to synthesise (11)C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [(11)C]MPEP has been radiolabelled using this technique.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbon Radioisotopes / chemistry*
Humans
Hydrocarbons, Aromatic / chemical synthesis
Hydrocarbons, Aromatic / chemistry*
Methylation
Palladium / chemistry*
Positron-Emission Tomography
Receptor, Metabotropic Glutamate 5 / chemistry

Substances

Carbon Radioisotopes
Hydrocarbons, Aromatic
Receptor, Metabotropic Glutamate 5
Palladium