Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy

Bojan Jelaković; Jovan Nikolić; Zoran Radovanović; Joelle Nortier; Jean-Pierre Cosyns; Arthur P Grollman; Nikolina Bašić-Jukić; Mladen Belicza; Danica Bukvić; Semra Čavaljuga; Dubravka Čvorišćec; Ante Cvitković; Živka Dika; Plamen Dimitrov; Ljubica Đukanović; Karen Edwards; Dušan Ferluga; Ljubica Fuštar-Preradović; Gheorghe Gluhovschi; Goran Imamović; Tratinčica Jakovina; Petar Kes; Ninoslav Leko; Zvonimir Medverec; Enisa Mesić; Marica Miletić-Medved; Frederick Miller; Nikola Pavlović; Josip Pasini; Stjepko Pleština; Momir Polenaković; Vladislav Stefanović; Karla Tomić; Senaid Trnačević; Ivana Vuković Lela; Ranka Štern-Padovan

doi:10.1093/ndt/gft384

Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy

Nephrol Dial Transplant. 2014 Nov;29(11):2020-7. doi: 10.1093/ndt/gft384. Epub 2013 Oct 28.

Authors

Bojan Jelaković¹, Jovan Nikolić², Zoran Radovanović³, Joelle Nortier⁴, Jean-Pierre Cosyns⁵, Arthur P Grollman⁶, Nikolina Bašić-Jukić¹, Mladen Belicza⁷, Danica Bukvić⁸, Semra Čavaljuga⁹, Dubravka Čvorišćec¹⁰, Ante Cvitković¹¹, Živka Dika¹, Plamen Dimitrov¹², Ljubica Đukanović³, Karen Edwards¹³, Dušan Ferluga¹⁴, Ljubica Fuštar-Preradović¹⁵, Gheorghe Gluhovschi¹⁶, Goran Imamović¹⁷, Tratinčica Jakovina¹⁵, Petar Kes¹, Ninoslav Leko¹⁸, Zvonimir Medverec¹⁹, Enisa Mesić¹⁷, Marica Miletić-Medved¹¹, Frederick Miller²⁰, Nikola Pavlović²¹, Josip Pasini²², Stjepko Pleština²³, Momir Polenaković²⁴, Vladislav Stefanović²⁵, Karla Tomić¹⁵, Senaid Trnačević¹⁷, Ivana Vuković Lela¹, Ranka Štern-Padovan²⁶

Affiliations

¹ School of Medicine, University of Zagreb, Department for Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia.
² Clinic of Urology Institute of Urology and Nephrology, Clinical Centre of Serbia, Belgrade, Serbia.
³ Schools of Medicine, University of Belgrade, Belgrade, Serbia.
⁴ Department of Nephrology, Erasme Hospital Universite Libre Bruxelles, Bruxelles, Belgium.
⁵ Department of Pathology, Cliniques Universitaires St-Luc Université Catholique de Louvain Medical School, Brussels, Belgium.
⁶ Department of Pharmacological Sciences, State University of New York at Stony Brook, New York, USA.
⁷ Department for Pathology, Clinical Hospital 'Sestre Milosrdnice' University of Zagreb, School of Medicine, Zagreb, Croatia.
⁸ Institute for Endemic Nephropathy, Lazarevac, Serbia.
⁹ Institute for Epidemiology, University of Sarajevo, Sarajevo, Bosnia and Hercegovina.
¹⁰ Department of Clinical Laboratory Diagnostics, University Hospital Center Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.
¹¹ Institute for Public Health, Brodsko Posavska County, Slavonski Brod, Croatia.
¹² Department of Biostatistics and Social Epidemiology, National Center for Public Health Protection, Sofia, Bulgaria.
¹³ Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine University of Washington, Seattle, WA, USA.
¹⁴ School of Medicine, University of Ljubljana, Ljubljana, Slovenia.
¹⁵ Department for Pathology and Forensic Medicine, General Hospital 'Dr.Josip Benčević' Slavonski Brod, Croatia.
¹⁶ University of Medicine and Pharmacy, Timisoara, Romania.
¹⁷ University Medical Center Tuzla, Tuzla, Bosnia and Herzegovina.
¹⁸ Department for Nephrology, General Hospital 'Dr.Josip Benčević' Slavonski Brod, Slavonski Brod, Croatia.
¹⁹ Department for Urology, General Hospital 'Dr. Josip Benčević' Slavonski Brod, Slavonski Brod, Croatia.
²⁰ Department of Pathology, State University of New York at Stony Brook, New York, USA.
²¹ Institute for Nephrology and Hemodialysis, Clinical Center, University of Niš, Niš, Serbia.
²² Department for Urology, School of Medicine University of Zagreb, University Hospital Center Zagreb, Zagreb, Croatia.
²³ Department for Oncology, University Hospital Center Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.
²⁴ Department of Nephrology, University 'Sts Ciril and Methodius' Faculty of Medicine and Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.
²⁵ Institute of Nephrology, Faculty of Medicine, Niš, Serbia.
²⁶ Department for Radiology, University Hospital Center Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.

Abstract

Currently used diagnostic criteria in different endemic (Balkan) nephropathy (EN) centers involve different combinations of parameters, various cut-off values and many of them are not in agreement with proposed international guidelines. Leaders of EN centers began to address these problems at scientific meetings, and this paper is the outgrowth of those discussions. The main aim is to provide recommendations for clinical work on current knowledge and expertise. This document is developed for use by general physicians, nephrologists, urologist, public health experts and epidemiologist, and it is hoped that it will be adopted by responsible institutions in countries harboring EN. National medical providers should cover costs of screening and diagnostic procedures and treatment of EN patients with or without upper urothelial cancers.

Keywords: aristolochic acid nephropathy; consensus statement; diagnostic criteria; endemic nephropathy; upper urothelial cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Balkan Nephropathy* / classification
Balkan Nephropathy* / diagnosis
Balkan Nephropathy* / therapy
Consensus*
Disease Management*
Humans
Mass Screening / methods*

Abstract

Publication types

MeSH terms

Grants and funding