Urease inhibitory activity of ursane type sulfated saponins from the aerial parts of Zygophyllum fabago Linn

Saleha Suleman Khan; Ajmal Khan; Afsar Khan; Abdul Wadood; Umar Farooq; Amir Ahmed; Aqib Zahoor; Viqar Uddin Ahmad; Bilge Sener; Nurgun Erdemoglu

doi:10.1016/j.phymed.2013.09.009

Urease inhibitory activity of ursane type sulfated saponins from the aerial parts of Zygophyllum fabago Linn

Phytomedicine. 2014 Feb 15;21(3):379-82. doi: 10.1016/j.phymed.2013.09.009. Epub 2013 Oct 29.

Authors

Affiliations

¹ H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: saleha_iccs@yahoo.com.
² H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
³ Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: afsarhej@yahoo.com.
⁴ Department of Biochemistry, Shankar Campus, Abdul Wali Khan University, Mardan, Pakistan.
⁵ Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
⁶ Pharmaceutical Division, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan.
⁷ H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: vuahmad@hotmail.com.
⁸ Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.

PMID: 24182987
DOI: 10.1016/j.phymed.2013.09.009

Abstract

Five ursane type sulfated saponins have been isolated from the aerial parts of Zygophyllum fabago Linn. (locally called Chashum). The urease inhibitory effects of these compounds have been investigated for the first time as well as their molecular docking studies have also been carried out to check the structure-activity relationship. The IC50 values of these compounds could not be found due to paucity of the samples. The molecular docking studies were performed only for the most active compound mono sodium salt of 3β,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-[β-D-glucopyranosyl] ester (Zygofaboside A; 1).

Keywords: Molecular docking; Sulfated saponins; Urease inhibitory activity; Ursane; Zygophyllum fabago.

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Molecular Docking Simulation
Plant Components, Aerial / chemistry
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Saponins / chemistry
Saponins / isolation & purification
Saponins / pharmacology*
Structure-Activity Relationship
Urease / antagonists & inhibitors*
Zygophyllum / chemistry*

Substances

3,23-di-O-sulfonyl-23-hydroxyurs-20(21)-en-28-oic acid 28-O-glucopyranosyl ester
Enzyme Inhibitors
Plant Extracts
Saponins
Urease