Correlation between circulating corticosterone and protein carbonylation in the liver after short-term hypokinesia

V E Tseilikman; N E Pankov; N A Pankova; T A Filimonova; A I Sinitskii; D A Kozochkin; O B Tseilikman

doi:10.1007/s10517-013-2307-x

Correlation between circulating corticosterone and protein carbonylation in the liver after short-term hypokinesia

Bull Exp Biol Med. 2013 Dec;156(2):188-90. doi: 10.1007/s10517-013-2307-x.

Authors

V E Tseilikman¹, N E Pankov, N A Pankova, T A Filimonova, A I Sinitskii, D A Kozochkin, O B Tseilikman

Affiliation

¹ Chelyabinsk State Medical Academy, Ministry of Healthcare of the Russian Federation, Chelyabinsk, Russia. vadimed@yandex.ru.

PMID: 24319745
DOI: 10.1007/s10517-013-2307-x

Abstract

We studied the correlation of the concentration of circulating corticosterone and parameters of dexamethasone suppression test with the level of protein carbonylation in the liver after short-term hypokinesia. Increasing hypokinesia duration was followed by worsening of disturbances in the hypothalamic-pituitary-adrenal system via a negative feedback mechanism and enhanced protein carbonylation in the liver.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Corticosterone / blood*
Dexamethasone / administration & dosage
Hypokinesia / blood*
Hypothalamo-Hypophyseal System / metabolism
Liver / metabolism*
Oxidative Stress
Protein Carbonylation*
Rats

Substances

Dexamethasone
Corticosterone