OLA1 in centrosome biology alongside the BRCA1/BARD1 complex: looking beyond centrosomes

Mol Cell. 2014 Jan 9;53(1):3-5. doi: 10.1016/j.molcel.2013.12.016.

Abstract

In this issue of Molecular Cell, Chiba and colleagues (Matsuzawa et al., 2014) identify Obg-like ATPase 1 (OLA1) as an additional member of the BRCA1/BARD1/γ-tubulin complex that is critically involved in centrosome amplification and microtubule aster formation.

Publication types

  • Review
  • Comment

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • BRCA1 Protein / metabolism*
  • Breast Neoplasms / metabolism*
  • Centrosome / metabolism*
  • Female
  • GTP-Binding Proteins / metabolism*
  • Humans

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • Adenosine Triphosphatases
  • GTP-Binding Proteins
  • OLA1 protein, human