Isolated involvement of spleen in tuberculosis is a rare entity, particularly among immunocompetent hosts. Herein, we present a 28-year-old man with left abdominal discomfort for 2 years who was found to have a cystic lesion in spleen on evaluation. Eventually, he was diagnosed to have isolated splenic tuberculosis with an involvement of a single lymph node at the splenic hilum. In this rare form of tuberculosis, it seems that splenectomy in addition to standard antitubercular therapy is curative.
Keywords: Isolated spleenic tuberculosis.