Avian influenza vaccines against H5N1 'bird flu'

Chengjun Li; Zhigao Bu; Hualan Chen

doi:10.1016/j.tibtech.2014.01.001

Avian influenza vaccines against H5N1 'bird flu'

Trends Biotechnol. 2014 Mar;32(3):147-56. doi: 10.1016/j.tibtech.2014.01.001. Epub 2014 Feb 1.

Authors

Chengjun Li¹, Zhigao Bu¹, Hualan Chen²

Affiliations

¹ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Nangang District, Harbin, China 150001.
² State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Nangang District, Harbin, China 150001. Electronic address: chenhualan@caas.cn.

PMID: 24491922
DOI: 10.1016/j.tibtech.2014.01.001

Abstract

H5N1 avian influenza viruses (AIVs) have spread widely to more than 60 countries spanning three continents. To control the disease, vaccination of poultry is implemented in many of the affected countries, especially in those where H5N1 viruses have become enzootic in poultry and wild birds. Recently, considerable progress has been made toward the development of novel avian influenza (AI) vaccines, especially recombinant virus vector vaccines and DNA vaccines. Here, we will discuss the recent advances in vaccine development and use against H5N1 AIV in poultry. Understanding the properties of the available, novel vaccines will allow for the establishment of rational vaccination protocols, which in turn will help the effective control and prevention of H5N1 AI.

Keywords: H5N1; avian influenza; vaccine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biotechnology / trends
Humans
Influenza A Virus, H5N1 Subtype / immunology*
Influenza Vaccines / therapeutic use*
Influenza, Human / prevention & control*
Mass Vaccination

Substances

Influenza Vaccines