Sixty odontogenic keratocysts were clinically, radiographically, and histologically examined to determine whether any significant relationships existed between the radiographic appearance of the odontogenic keratocyst (unilocular versus multilocular) and its corresponding clinical and histologic features. The odontogenic keratocysts identified as multilocular appeared to be larger, contain a more severe inflammation, and exhibit the presence of cholesterol granulomas more often than those identified as unilocular.