Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84

Taylor A Doherty; David Scott; Hannah H Walford; Naseem Khorram; Sean Lund; Rachel Baum; Jinny Chang; Peter Rosenthal; Andrew Beppu; Marina Miller; David H Broide

doi:10.1016/j.jaci.2013.12.1086

Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84

J Allergy Clin Immunol. 2014 Apr;133(4):1203-5. doi: 10.1016/j.jaci.2013.12.1086. Epub 2014 Feb 28.

Authors

Affiliations

¹ Department of Medicine, University of California, San Diego, La Jolla, Calif. Electronic address: tdoherty@ucsd.edu.
² Department of Medicine, University of California, San Diego, La Jolla, Calif; Division of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, Calif.
³ Department of Medicine, University of California, San Diego, La Jolla, Calif; Rady's Children's Hospital of San Diego, Division of Rheumatology, Allergy and Immunology, San Diego, Calif.
⁴ Department of Medicine, University of California, San Diego, La Jolla, Calif.

Abstract

Type 2 innate lymphoid cells (ILC2) produce high levels of Th2 cytokines. Our study demonstrates that cat allergen challenge in allergic rhinitis subjects rapidly induces increased peripheral blood ILC2.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Allergens / administration & dosage
Allergens / immunology*
Antigens, CD / metabolism*
Humans
Lymphocytes / immunology*
Lymphocytes / metabolism*
Rhinitis, Allergic
Rhinitis, Allergic, Perennial / immunology*
Rhinitis, Allergic, Perennial / metabolism*
Signaling Lymphocytic Activation Molecule Family

Substances

Allergens
Antigens, CD
CD84 protein, human
Signaling Lymphocytic Activation Molecule Family

Abstract

Publication types

MeSH terms

Substances

Grants and funding