Cationic liposome-mediated transfection

P L Felgner; G M Ringold

doi:10.1038/337387a0

Cationic liposome-mediated transfection

Nature. 1989 Jan 26;337(6205):387-8. doi: 10.1038/337387a0.

Authors

P L Felgner¹, G M Ringold

Affiliation

¹ Vical, Inc., San Diego, California 92121.

PMID: 2463491
DOI: 10.1038/337387a0

Abstract

A lipid named DOTMA has been created that forms unilamellar liposomes which complex with DNA and RNA for the transfection of mammalian cells, including suspension cells and hybridomas.

MeSH terms

DNA / genetics
Liposomes*
Quaternary Ammonium Compounds*
RNA / genetics
Transfection*

Substances

Liposomes
Quaternary Ammonium Compounds
N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium
RNA
DNA