Abstract
We report on pH-responsive core-shell polymer micelles with catechol-Fe(3+) coordinated core cross-links, which provide robustness to drug-loaded polymer micelles and allow the facilitated intracellular release of loaded anticancer drugs in response to an endosomal acidic pH.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Catechols / chemistry
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Cell Proliferation / drug effects
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Doxorubicin / chemistry
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Doxorubicin / pharmacology
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Drug Carriers / chemistry
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Ferric Compounds / chemistry*
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Humans
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Hydrogen-Ion Concentration
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Ligands
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MCF-7 Cells
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Micelles*
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Polymers / chemistry*
Substances
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Antineoplastic Agents
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Catechols
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Drug Carriers
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Ferric Compounds
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Ligands
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Micelles
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Polymers
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Doxorubicin
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catechol