Screening occupational contact allergy to bisphenol F epoxy resin

Contact Dermatitis. 2014 Sep;71(3):138-44. doi: 10.1111/cod.12223. Epub 2014 Apr 2.

Abstract

Background: Epoxy resins based on diglycidyl ether of bisphenol F (DGEBF) are widely used as such in applications requiring chemical resistance, and also together with diglycidyl ether of bisphenol A resin (DGEBA-R). Concomitant patch test reactions to DGEBA-R and DGEBF resin (DGEBF-R) are common. Previous studies have yielded conflicting results on the frequency of independent DGEBF-R contact allergies.

Objectives: To report the results of over 11 years of screening with DGEBF-R.

Methods: An in-house test substance of DGEBF-R (Epikote 862) was tested in the baseline patch test series, first at 1% and later at 0.25%. Test files were screened for allergic reactions to DGEBF-R and DGEBA-R, and the clinical records of positively reacting patients were analysed for occupation and exposure.

Results: Among 1972 patients, 66 (3.3%) reacted to DGEBF-R and 96 (4.9%) to DGEBA-R. Independent DGEBF-R allergies were seen in 5 patients only, and independent DGEBA-R allergies in 35. Specific exposure to DGEBF-R was found in 26 patients. The main occupational fields were the aircraft industry, the electrical and sports equipment industry, boat building, painting/floor coating, tile setting, and pipe relining.

Conclusions: Independent contact allergies to DGEBF-R were rare, and screening with it was not found to be useful.

Keywords: Epikote® 862; composites; cross-allergy; diglycidyl ether of bisphenol A (DGEBA); diglycidyl ether of bisphenol F (DGEBF); patch test.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzhydryl Compounds / adverse effects*
  • Benzhydryl Compounds / chemistry
  • Dermatitis, Allergic Contact / diagnosis*
  • Dermatitis, Allergic Contact / epidemiology
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Occupational / diagnosis*
  • Dermatitis, Occupational / epidemiology
  • Dermatitis, Occupational / etiology*
  • Epoxy Compounds / adverse effects*
  • Epoxy Compounds / chemistry
  • Epoxy Resins / adverse effects*
  • Epoxy Resins / chemistry
  • Female
  • Finland / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Molecular Structure
  • Patch Tests
  • Phenols / adverse effects*
  • Phenols / chemistry
  • Prevalence

Substances

  • Benzhydryl Compounds
  • Epoxy Compounds
  • Epoxy Resins
  • Phenols
  • bisphenol A
  • bisphenol F diglycidyl ether