A switchable peptide sensor for real-time lysosomal tracking

Lei Chen; Junchen Wu; Carsten Schmuck; He Tian

doi:10.1039/c4cc00670d

A switchable peptide sensor for real-time lysosomal tracking

Chem Commun (Camb). 2014 Jun 21;50(49):6443-6. doi: 10.1039/c4cc00670d. Epub 2014 Apr 9.

Authors

Lei Chen¹, Junchen Wu, Carsten Schmuck, He Tian

Affiliation

¹ Key Labs for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. jcwu@ecust.edu.cn tianhe@ecust.edu.cn.

PMID: 24714849
DOI: 10.1039/c4cc00670d

Abstract

A bis-spiropyran functionalized peptide 1, which exhibits good cell-permeability, excellent biocompatibility and low cytotoxicity, has been developed for reversible and real-time lysosomal tracking.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzopyrans / chemistry*
Cell Line, Tumor
Cell Membrane Permeability
Fluorescent Dyes / chemistry
Humans
Hydrogen-Ion Concentration
Indoles / chemistry*
Lysosomes / chemistry
Lysosomes / metabolism*
Microscopy, Fluorescence
Nitro Compounds / chemistry*
Peptides / chemistry*
Peptides / metabolism
Spectrometry, Fluorescence
Time-Lapse Imaging
Ultraviolet Rays

Substances

Benzopyrans
Fluorescent Dyes
Indoles
Nitro Compounds
Peptides
spiropyran