Background: Ghrelin, a 28 amino acid peptide, is effective in control of appetite and body weight. Acylated ghrelin peptide is the active form of this peptide which plays a major role in the body's energy balance.
Objectives: This study aimed to investigate the possible effect (s) of intensive resistance exercise on acylated ghrelin, growth hormone, glucose, insulin, and cortisol plasma levels.
Patients and methods: Forty male students with the mean age of 19.22 ± 0.26 years and BMI 21.02 ± 0.33 (kg/m(2)) were randomly divided into experimental and control groups. Experimental group performed a single session of circuit resistance exercise with 80% 1RM in both fasting and high carbohydrate meal. Blood samples were collected before and immediately after exercise to measure the concentrations of mentioned variables.
Results: Two-way ANOVA showed that acylated ghrelin and fasting plasma glucose levels after exercise in both high-carbohydrate and fasting groups were significantly increased compared to the control group (P < 0.05), but the levels of insulin, cortisol, and growth hormones did not have any significant change.
Conclusions: Totally, it seems that the increased plasma acylated ghrelin during exercise is due to the decrease of muscle and liver energy stores which provides conditions for increased energy intake and positive energy balance.
Keywords: Carbohydrate; Ghrelin; Resistance Training.