Management of chronic heart failure: biomarkers, monitors, and disease management programs

Ann Glob Health. 2014 Jan-Feb;80(1):46-54. doi: 10.1016/j.aogh.2013.12.005. Epub 2013 Dec 25.

Abstract

Background: The management of patients with heart failure has been evolving given the complex nature of the disease and the increasing number of patients.

Findings: Biomarkers, and in particular the natriuretic peptides, have been studied to assist with diagnosis, chronic management, and prognosis in patients with heart failure. Several new biomarkers are emerging and may be used individually or in combination with the natriuretic peptides. The use of cardiac monitoring devices and disease management programs is being established to assist in the care of patients with chronic heart failure. Interventions using phone calls, telemedicine devices, intracardiac pressure monitors, and implantable cardioverter defibrillators have been investigated.

Conclusions: The combination of biomarkers, monitoring devices, and disease management programs shows promise for improving care in this challenging patient population.

Keywords: biomarkers; cardiac monitors; disease management programs; heart failure; natriuretic peptides.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins
  • Biomarkers / blood
  • Cardio-Renal Syndrome / blood
  • Chronic Disease
  • Cystatin C / blood
  • Heart Failure / diagnosis*
  • Heart Failure / therapy*
  • Humans
  • Lipocalin-2
  • Lipocalins / blood
  • Monitoring, Ambulatory / instrumentation
  • Natriuretic Peptides / blood*
  • Proto-Oncogene Proteins / blood
  • Telemedicine
  • Troponin / blood*

Substances

  • Acute-Phase Proteins
  • Biomarkers
  • Cystatin C
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Natriuretic Peptides
  • Proto-Oncogene Proteins
  • Troponin