Risk adapted high-dose and dose-dense therapies modulate the impact of biological classification in diffuse large B-cell lymphoma prognosis

Santiago Montes-Moreno; Ana Batlle; Sonia González de Villambrosía; Beatriz Sánchez-Espiridión; Laura Cereceda; Eva González-Barca; Noelia Purroy; Emilia Pardal; Alejandro Martín; Carlos Grande; Francisco Mazorra; Andrés Insunza; Cristina Quero; David Aguiar; Miguel Angel Cruz; Antonio Rueda; Marta Llanos; José Gómez Codina; Francisco Ramón García Arroyo; Dolores Caballero; Eulogio Conde; Andrés López; Mariano Provencio; Miguel Piris

doi:10.3324/haematol.2014.104976

Risk adapted high-dose and dose-dense therapies modulate the impact of biological classification in diffuse large B-cell lymphoma prognosis

Haematologica. 2014 Aug;99(8):e138-41. doi: 10.3324/haematol.2014.104976. Epub 2014 Apr 24.

Authors

Santiago Montes-Moreno¹, Ana Batlle², Sonia González de Villambrosía³, Beatriz Sánchez-Espiridión⁴, Laura Cereceda⁴, Eva González-Barca⁵, Noelia Purroy⁶, Emilia Pardal⁷, Alejandro Martín⁸, Carlos Grande⁹, Francisco Mazorra¹⁰, Andrés Insunza¹¹, Cristina Quero¹², David Aguiar¹³, Miguel Angel Cruz¹⁴, Antonio Rueda¹⁵, Marta Llanos¹⁶, José Gómez Codina¹⁷, Francisco Ramón García Arroyo¹⁸, Dolores Caballero⁸, Eulogio Conde³, Andrés López⁶, Mariano Provencio¹⁹, Miguel Piris¹⁰

Affiliations

¹ Pathology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain GELTAMO Group, Spanish Society of Hematology, Santander, Spain smontes@humv.es.
² Department of Hematology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
³ GELTAMO Group, Spanish Society of Hematology, Santander, Spain Department of Hematology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
⁴ Grupo de Genómica del Cáncer, IDIVAL, Santander, Spain.
⁵ GELTAMO Group, Spanish Society of Hematology, Santander, Spain Servicio de Hematología Clínica, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain.
⁶ PETHEMA, Programa Español de tratamientos en Hematología, L'Hospitalet de Llobregat, Barcelona, Spain Department of Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
⁷ GELTAMO Group, Spanish Society of Hematology, Santander, Spain Department of Hematology, Hospital Virgen del PuertoPlasencia, Salamanca, Spain.
⁸ GELTAMO Group, Spanish Society of Hematology, Santander, Spain Department of Hematology, Hospital Universitario de Salamanca/IBSAL, Salamanca, Spain.
⁹ GELTAMO Group, Spanish Society of Hematology, Santander, Spain Department of Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain.
¹⁰ Pathology Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
¹¹ GELTAMO Group, Spanish Society of Hematology, Santander, Spain.
¹² GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.
¹³ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital Universitario de Gran Canaria, Dr Negrín, Gran Canaria, Spain.
¹⁴ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital Virgen de la Salud, Toledo, Spain.
¹⁵ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital Costa del Sol, Marbella, Spain.
¹⁶ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital Universitario de Canarias, La Laguna, Spain.
¹⁷ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital La Fe, Valencia, Spain.
¹⁸ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital de Pontevedra, Madrid, Spain.
¹⁹ GOTEL (Grupo Oncológico para el Tratamiento de las Enfermedades Linfoides), L'Hospitalet de Llobregat, Barcelona, Spain Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.

No abstract available

Keywords: biological classification; diffuse large B-cell lymphoma; dose-dense therapies; high-dose.

Publication types

Clinical Trial
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Cyclophosphamide / administration & dosage
Dose-Response Relationship, Drug
Doxorubicin / administration & dosage
Female
Follow-Up Studies
Humans
Lymphoma, Large B-Cell, Diffuse / classification
Lymphoma, Large B-Cell, Diffuse / diagnosis*
Lymphoma, Large B-Cell, Diffuse / drug therapy*
Male
Middle Aged
Prednisone / administration & dosage
Prognosis
Risk Adjustment / methods*
Stem Cell Transplantation* / methods
Vincristine / administration & dosage
Young Adult

Substances

Vincristine
Doxorubicin
Cyclophosphamide
Prednisone

Supplementary concepts

CHOP protocol