Somatomedin-binding proteins: what role do they play in the growth process?

S Cianfarani; J M Holly

doi:10.1007/BF01995850

Somatomedin-binding proteins: what role do they play in the growth process?

Eur J Pediatr. 1989 Nov;149(2):76-9. doi: 10.1007/BF01995850.

Authors

S Cianfarani¹, J M Holly

Affiliation

¹ Department of Paediatrics, Tor Vergata University Medical School, II University of Rome, Italy.

PMID: 2480240
DOI: 10.1007/BF01995850

Abstract

The insulin-like growth factors (IGF-I and IGF-II) circulate bound to specific proteins. Two classes of binding proteins have been relatively well characterized differing in size, immunological activity, and physiological function. This review summarizes the more recent data on IGF-binding proteins, focusing on their possible clinical implications.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Carrier Proteins / pharmacology*
Carrier Proteins / physiology
Growth / drug effects*
Humans
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I / biosynthesis
Insulin-Like Growth Factor II / biosynthesis
Somatomedins / pharmacology*

Substances

Carrier Proteins
Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II