Abstract
One class of excitatory amino acid (EAA) receptor, the N-methyl-D-aspartate (NMDA) receptor, has excited enormous interest because of its unique pharmacological and physiological properties. Yet another property of this receptor/channel complex has recently emerged: its activation is greatly enhanced by and may even be dependent on, sub-micromolar concentrations of glycine.
MeSH terms
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Amino Acids / metabolism
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Evoked Potentials / drug effects
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Glycine / antagonists & inhibitors
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Glycine / pharmacology*
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Humans
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Ion Channels / drug effects
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Ion Channels / physiology
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Neurons / physiology
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology*
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Synapses / drug effects
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Synapses / physiology
Substances
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Amino Acids
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Ion Channels
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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Glycine