Managing coeliac disease in patients with diabetes

Diabetes Obes Metab. 2015 Jan;17(1):3-8. doi: 10.1111/dom.12310. Epub 2014 May 29.

Abstract

The association between coeliac disease and type 1 diabetes has long been established. The combination of genetic susceptibility along with a potential role for gluten in the pathogenesis of autoimmunity makes defining gluten's role in type 1 diabetes extremely important. Evidence supporting the role of a gluten-free diet to improve complications associated with type 1 diabetes is not robust. However there is evidence to support improved growth, bone density and potentially the prevention of additional autoimmune diseases in patients with coeliac disease and type 1 diabetes. The gluten free diet is expensive and challenging to adhere to in people already on a modified diet. Early identification of those who have coeliac disease and would benefit from a gluten-free diet is of utmost importance to prevent complications associated with type 1 diabetes and coeliac disease.

Keywords: coeliac disease; gluten-free diet; type 1 diabetes.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity*
  • Celiac Disease / complications
  • Celiac Disease / diet therapy*
  • Celiac Disease / immunology
  • Celiac Disease / physiopathology
  • Diabetes Complications / prevention & control
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / diet therapy*
  • Diabetes Mellitus, Type 1 / immunology
  • Diet, Diabetic* / adverse effects
  • Diet, Gluten-Free* / adverse effects
  • Evidence-Based Medicine*
  • Humans
  • Patient Compliance
  • Severity of Illness Index