Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs

Yanlin Zhao; George S Yap

doi:10.1016/j.chom.2014.05.002

Toxoplasma's arms race with the host interferon response: a ménage à trois of ROPs

Cell Host Microbe. 2014 May 14;15(5):517-8. doi: 10.1016/j.chom.2014.05.002.

Authors

Yanlin Zhao¹, George S Yap²

Affiliations

¹ Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07101, USA.
² Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, NJ 07101, USA. Electronic address: yapgs@njms.rutgers.edu.

Abstract

The Toxoplasma gondii virulence factors ROP5 and ROP18 both target immunity-related GTPases (IRGs) to evade immunity. In this issue of Cell Host & Microbe, Etheridge et al. (2014) identify a third virulence factor, ROP17, which forms a complex and synergizes with ROP5/ROP18 to fully disable the IRG system of antiparasite defense.

Publication types

Comment

MeSH terms

Animals
Humans
Protein Serine-Threonine Kinases / metabolism*
Protozoan Proteins / metabolism*
Toxoplasma / enzymology*
Toxoplasma / pathogenicity*
Toxoplasmosis / parasitology*

Substances

Protozoan Proteins
Protein Serine-Threonine Kinases

Grants and funding

R01 AI083405/AI/NIAID NIH HHS/United States