Abstract
In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / metabolism
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Animals
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / metabolism
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Arthritis, Rheumatoid / drug therapy*
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Arthritis, Rheumatoid / metabolism
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Arthritis, Rheumatoid / pathology
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Cell Line
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Drug Combinations
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Drug Delivery Systems / methods*
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Hyaluronic Acid / administration & dosage*
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Hyaluronic Acid / metabolism
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Methotrexate / administration & dosage*
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Methotrexate / metabolism
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Mice
Substances
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Adjuvants, Immunologic
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Antirheumatic Agents
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Drug Combinations
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Hyaluronic Acid
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Methotrexate