The potential of adipokines as therapeutic agents for cardiovascular disease

Cytokine Growth Factor Rev. 2014 Aug;25(4):483-7. doi: 10.1016/j.cytogfr.2014.07.005. Epub 2014 Jul 11.

Abstract

Adipose tissue functions as an endocrine organ by producing bioactive secretory proteins, also known as adipokines, that can directly act on nearby or remote organs. Most of the adipokines are upregulated by obese conditions, and typically promote obese complications. In contrast, some adipokines, such as adiponectin, CTRP9 and omentin, are downregulated in obese states. These factors exert salutary actions on obesity-linked cardiovascular disorders. In this review, we focus on the significance of adiponectin, CTRP9 and omentin as therapeutic agents for cardiovascular disease.

Keywords: Adipokines; Adiponectin; CTRP9; Cardiovascular disease; Omentin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipokines / pharmacology*
  • Adipokines / therapeutic use*
  • Adiponectin / pharmacology
  • Adipose Tissue / metabolism
  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cytokines / pharmacology
  • GPI-Linked Proteins / pharmacology
  • Humans
  • Lectins / pharmacology
  • Mice
  • Obesity

Substances

  • Adipokines
  • Adiponectin
  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins