Towards the Development of Smart 3D "gated scaffolds" for on-command delivery

Small. 2014 Dec 10;10(23):4859-64. doi: 10.1002/smll.201401227. Epub 2014 Jul 30.

Abstract

A new approach towards the design of "gated scaffolds" based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able to selectively deliver cargo in the presence of an APase enzyme is prepared and tested. This new design opens up the possibility of developing new smart biomaterials with advanced drug-delivery features.

Keywords: 3D scaffolds; biomaterials; controlled release; mesoporous silica nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Anions
  • Biocompatible Materials / chemistry*
  • Drug Carriers*
  • Drug Delivery Systems*
  • Gels / chemistry
  • Hydrogen Bonding
  • Imaging, Three-Dimensional / methods*
  • Materials Testing
  • Microscopy, Electron, Scanning
  • Nanoparticles / chemistry
  • Nanotechnology / methods
  • Porosity
  • Regeneration
  • Silicon Dioxide / chemistry
  • Tissue Engineering / methods
  • X-Ray Diffraction

Substances

  • Anions
  • Biocompatible Materials
  • Drug Carriers
  • Gels
  • Silicon Dioxide
  • Adenosine Triphosphate