Abstract
A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / chemistry
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Alkynes / chemical synthesis
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Alkynes / chemistry*
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Carboxylic Acids / chemistry*
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Catalysis
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Copper / chemistry*
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Decarboxylation
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Esters
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Oxides / chemical synthesis*
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Oxides / chemistry
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Phosphines / chemical synthesis*
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Phosphines / chemistry
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Stereoisomerism
Substances
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Alkenes
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Alkynes
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Carboxylic Acids
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Esters
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Oxides
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Phosphines
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Copper