High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions

Haematologica. 2014 Dec;99(12):e257-9. doi: 10.3324/haematol.2014.110437. Epub 2014 Aug 22.

Authors

Florentien E M in 't Hout¹, Bert A van der Reijden², Davide Monteferrario¹, Joop H Jansen², Gerwin Huls³

Affiliations

¹ Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and Department of Hematology, RadboudUMC, Nijmegen, The Netherlands.
² Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and.
³ Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and Department of Hematology, RadboudUMC, Nijmegen, The Netherlands gerwin.huls@radboudumc.nl.

No abstract available

Keywords: AML; TCF4; treatment.

Publication types

Letter

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics*
Biomarkers, Tumor / genetics*
Cohort Studies
Combined Modality Therapy
Female
Follow-Up Studies
Gene Expression Profiling
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / mortality
Leukemia, Myeloid, Acute / therapy
Male
Middle Aged
Neoplasm Staging
Oligonucleotide Array Sequence Analysis
Prognosis
RNA, Messenger / genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Transcription Factor 4
Transcription Factors / genetics*
Transplantation, Autologous

Substances

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Biomarkers, Tumor
RNA, Messenger
TCF4 protein, human
Transcription Factor 4
Transcription Factors